ISSN: 0973-7510

E-ISSN: 2581-690X

Review Article | Open Access
Anchana Devi1 , T. Ramani Devi2, N. Pushpa3 and Dharani Vijayakumar1
1PG & Research Department of Biotechnology, Women’s Christian College, An Autonomous Institution Affiliated to University of Madras, Chennai – 600 006, Tamilnadu, India.
2Senior Consultant in Obstetrics & Gynaecology, Ramakrishna Medical Centre, Tiruchirapalli – 620 003, Tamilnadu, India.
3Department of Microbiology, Cauvery College for Women, An Autonomous Institution Affiliated to Bharathidasan University, Tiruchirapalli – 620 018, Tamilnadu, India.
Article Number: 7188 | © The Author(s). 2022
J Pure Appl Microbiol. 2022;16(3):1506-1518. https://doi.org/10.22207/JPAM.16.3.05
Received: 17 July 2021 | Accepted: 16 May 2022 | Published online: 07 July 2022
Issue online: September 2022
Abstract

Cervical cancer (CC) contributes to 6%-29% of all cancers in women. In India, 527,624 new cases of CC are added every year. India contributes to ¼ of deaths worldwide to CC it occurs often in women around the age of 30 yrs which is contributed by a specific kind of human papillomavirus causes long-term infection and inflammation (HPV) which result in morphological changes in the cells of cervix the region that connect vagina and uterus. Cervicovaginal microbiome is observed to be highly diverse among patients with CC where there is reduced number of Latobacillus spp that leads to dysbiosis and decrease in pH and eventually colonised by other anaerobic bacteria. The shift in community state types (CST) is highly associated with the Human Papillomavirus infection and its further progression to cervical dysplasia or CIN i.e. ‘Cervical intraepithelial neoplasia’ and malignant tumour of the cervix uteri. The purpose of this research is to figure out if there’s a link between the cervico-vaginal microbiota and gynaecological cancer and the review also focuses whether cervical microbiome signatures can predict the severity of infection leading to development of CC? Probiotics can be used as a potential alternative to balance the dysbiosis of the cervicovaginal environment. Hence the review summarizes the current knowledge and the interaction of different bacterial groups with Human Papilloma Virus infection and development of CC.

Keywords

Cervical Cancer (CC), Vaginal Microbiome (VMB), Probiotics, Human Papilloma Virus

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