ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access
Noushad Karuvantevida1, Muthusamy Razia2, Ramalingam Bhuvaneshwar1, Gnanasekar Sathishkumar1, Seetharaman Prabukumar1 and Sivaperumal Sivaramakrishnan1
1Department of Biotechnology, Bharathidsasan University, Tiruchirappalli – 620 024, Tamilnadu, India.
2Department of Biotechnology, Mother Teresa Women’s University, Kodaikanal – 624-101, Tamilnadu, India.
Article Number: 7711 | © The Author(s). 2022
J Pure Appl Microbiol. 2022;16(3):1652-1662.
Received: 27 March 2022 | Accepted: 15 June 2022 | Published online: 28 June 2022
Issue online: September 2022

The multifunctional features of noble metal nanoparticles (MNPs) were exploited in various biomedical applications, which eventually demanded the development of a sustainable green synthesis approach. In the present study, Quercetin (Q) was employed as a promising green reductant for the generation of noble metal nanoparticles such as silver (Q-AgNPs), gold (Q-AuNPs), and bimetallic (Q-Ag-AuNPs) towards biomedical perspective. Initially, the NPs were successfully synthesized in a size-controlled manner via optimizing temperature, pH, metal ion concentration, and stoichiometric ratio of the reaction mix. The redox reaction and conversion of metal ions (Ag+ and Au3+) into their respective metal nano-forms were confirmed through their surface plasmonic resonance (SPR) in UV-visible spectroscopy. In addition, different instrumentation like FT-IR, XRD, HR-TEM, and XPS analyses were performed to confirm the size, shape, and chemical composition of fabricated NPs. The bactericidal effect of fabricated NPs was tested against Gram-positive and Gram-negative pathogens. Moreover, the cytotoxic potential was screened against breast (MCF-7) and colorectal (HCT-116) carcinoma cell lines. This work revealed that the flavonoid-functionalized noble metal NPs were associated with good antibacterial and anticancer potential against selected cancer cell lines.


Quercetin, Silver Nanoparticles, Bi-metallic, Green Synthesis, Antibacterial, Breast Carcinoma

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© The Author(s) 2022. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.