ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access
Noushad Karuvantevida1, Muthusamy Razia2, Ramalingam Bhuvaneshwar1, Gnanasekar Sathishkumar1, Seetharaman Prabukumar1 and Sivaperumal Sivaramakrishnan1
1Department of Biotechnology, Bharathidsasan University, Tiruchirappalli – 620 024, Tamilnadu, India.
2Department of Biotechnology, Mother Teresa Women’s University, Kodaikanal – 624-101, Tamilnadu, India.
Article Number: 7711 | © The Author(s). 2022
J Pure Appl Microbiol. 2022;16(3):1652-1662. https://doi.org/10.22207/JPAM.16.3.03
Received: 27 March 2022 | Accepted: 15 June 2022 | Published online: 28 June 2022
Issue online: September 2022
Abstract

The multifunctional features of noble metal nanoparticles (MNPs) were exploited in various biomedical applications, which eventually demanded the development of a sustainable green synthesis approach. In the present study, Quercetin (Q) was employed as a promising green reductant for the generation of noble metal nanoparticles such as silver (Q-AgNPs), gold (Q-AuNPs), and bimetallic (Q-Ag-AuNPs) towards biomedical perspective. Initially, the NPs were successfully synthesized in a size-controlled manner via optimizing temperature, pH, metal ion concentration, and stoichiometric ratio of the reaction mix. The redox reaction and conversion of metal ions (Ag+ and Au3+) into their respective metal nano-forms were confirmed through their surface plasmonic resonance (SPR) in UV-visible spectroscopy. In addition, different instrumentation like FT-IR, XRD, HR-TEM, and XPS analyses were performed to confirm the size, shape, and chemical composition of fabricated NPs. The bactericidal effect of fabricated NPs was tested against Gram-positive and Gram-negative pathogens. Moreover, the cytotoxic potential was screened against breast (MCF-7) and colorectal (HCT-116) carcinoma cell lines. This work revealed that the flavonoid-functionalized noble metal NPs were associated with good antibacterial and anticancer potential against selected cancer cell lines.

Keywords

Quercetin, Silver Nanoparticles, Bi-metallic, Green Synthesis, Antibacterial, Breast Carcinoma

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