ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access
Rania Ahmed Hassan1, Mona A. Khattab1 , Hieba Gamal Ezzelregal2, Heba Mohamed Tawfik3, Shimaa Hussien Gadallah4, Dalia Hosni Abdelhamid5 and Yasmin Mohamed Ahmed1
1Departments of Medical Microbiology and Immunology, Faculty of Medicine-Ain Shams University, Cairo, Egypt.
2Chest, Faculty of Medicine-Ain Shams University, Cairo, Egypt.
3Geriatrics and Geronology, Faculty of Medicine-Ain Shams University, Cairo, Egypt.
4Internal Medicine and Gasteroenterology, Faculty of Medicine-Ain Shams University, Cairo, Egypt.
5Clinical Pathology, Faculty of Medicine-Ain Shams University, Cairo, Egypt.
J Pure Appl Microbiol. 2022;16(2):1298-1306 | Article Number: 7537 | © The Author(s). 2022
Received: 10/01/2022 | Accepted: 25/04/2022 | Published online: 01/06/2022
Issue online: June 2022

Patients with coronavirus disease-19 (COVID-19) present as mildly, moderately, or severely and critically ill. Cytokine storm is responsible for fatal pneumonia and acute respiratory distress syndrome. Interferon-γ-induced protein-10 (IP-10) and chemokine ligand-7 (CCL-7) are chemokines that play a role in the chemotaxis of inflammatory cells and the release of pro-inflammatory cytokines. In this study, we assessed the serum levels of IP-10 and CCL-7 chemokines in COVID-19 patients and their correlation with disease severity and prognosis. The serum levels of CCL-7 and IP-10 were assessed in 67 COVID-19 patients and 10 healthy controls. Serum samples were collected and examined for these two markers using direct enzyme-linked immunosorbent assay. Patients were divided into two groups according to their disease severity. Serum levels of the test markers were compared between patients and controls, and between patients with different disease severities and correlated with other clinical and laboratory parameters. CCL-7 and IP-10 levels were significantly higher in patients than in controls and in severe than in mild/moderate cases. The receiver operating characteristic curve analysis of the two markers showed better performance of the combined markers as predictors of disease severity (area under the curve = 0.792). The results of our study suggest a potential role of IP-10 and CCL-7 as predictors of COVID-19 severity.


Pandemic, COVID-19, IP-10, CCL-7

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© The Author(s) 2022. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.