ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access
Balamurali Venkatesan1, Leela Kakithakara Vajravelu1, Sujith Ravi1 , Jayaprakash Thulukanam1 and Om Lokesh Muthamilan2
1SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu – 603203, Tamil Nadu, India.
2Kasturba Medical College, Hampankatta, Mangalore – 575 001, Karnataka, India.
J Pure Appl Microbiol. 2022;16(2):1187-1191 | Article Number: 7596
https://doi.org/10.22207/JPAM.16.2.47 | © The Author(s). 2022
Received: 04/02/2022 | Accepted: 26/04/2022 | Published online: 31/05/2022
Issue online: June 2022
Abstract

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) possess high mortality and morbidity across the globe. In India, BBV-152 (CovaxinTM) and ChAdOx1-nCOV (CovishieldTM) vaccines are now being used to limit the spread of SARS-CoV-2 Infection. A Cross sectional observational study was designed to analyze the Antibody immune response to SARS CoV-2 vaccine quantitatively among Health Care Workers and it was correlated with age, sex, other comorbidities and blood group. A total of 160 fully vaccinated HCWs, the Anti-SARS-CoV-2 level was estimated by using Chemiluminescence Immuno Assay. A protective immune response following the complete course of the SARS-CoV-2 vaccine should be ≥ 1.00 S/C. A total of 160 HCWs (82 Male, 78 Female) who had completed both the doses of Covishield (n=128) and Covaxin (n=32). Both the vaccine recipient had mild to moderate symptoms and none of the HCWs had severe adverse events after administration of vaccine. Out of which, 143 (89.3%) HCWs showed seropositive and 17 (10.7%) HCWs showed seronegative. There was no notable variation in sex and other co-morbidities. Significantly, reduced antibody titers towards SARS-CoV-2 vaccine was noted among individuals aged ≤ 60 years and O+ve Blood group. Both the vaccines obtained successful immune response after their complete course, even though there was a significantly higher seropositivity rate in Covishield in spite of Covaxin recipients. Further, genomic correlative advanced studies can conclude the significance of non-responsiveness to SARS-CoV-2 vaccines among the HCWs.

Keywords

SARS-CoV-2 infection, SARS-CoV-2 Vaccines, Health Care Workers, Antibody immune response to SARS-CoV-2, Non Responsiveness

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