ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access
T. Jayaprakash1 , Om Lokesh Muthamilan2, K.V. Leela1, C. Panchapakesa Rajendran3, Arul Raja Murugan4 and Sujith Ravi5
1Department of Microbiology, SRM Medical College Hospital and Research Centre, Kattankulathur, Chennai – 603 203, Tamilnadu, India.
2Kasturba Medical College, Tiger Circle Road, Madhav Nagar, Manipal – 576 104, Karnataka, India.
3Department of Rheumatology, SRM Medical College Hospital and Research Centre, Kattankulathur, Chennai – 603 203, Tamilnadu, India.
4Department of Rheumatology, Madras Medical College, Chennai – 600 003, Tamilnadu, India.
5Department of Microbiology, SRM Medical College Hospital and Research Centre, Faculty of Medicine and Health Sciences, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu District, Tamil Nadu, India.
J Pure Appl Microbiol. 2022;16(2):901-908 | Article Number: 7561
https://doi.org/10.22207/JPAM.16.2.10 | © The Author(s). 2022
Received: 22/01/2022 | Accepted: 24/02/2022 | Published online: 25/04/2022
Issue online: June 2022
Abstract

Human leukocyte antigens (HLA) are gene products found in the major histocompatibility complex, aiding in differentiation of “self” from “non-self” antigens, and is crucial for the communication between immune cells of the human body. HLA-B27, in specific, has a strong interrelation with different types of Spondyloarthritis (SpA). The aim of this study is to study the frequency of HLA-B27 in suspected Spondyloarthritis patients presenting with axial and peripheral joint involvement, who attended our tertiary care centre from August-2017 to January-2021. Patients fulfilling Assessment of Spondyloarthritis International Society (ASAS) criteria for Spondyloarthritis were included in the study, and were further classified into Spondyloarthritis sub-groups. Blood samples were collected for CRP and ESR tests along with HLA-B27 detection by RT-PCR method. Magnetic resonance imaging was done for sacroiliac joints in patients with lower back pain. Analysis of 289 samples of SpA patients revealed 156 (54%) to be HLA-B27 positive and 133 (46%) to be HLA-B27 negative. There were 98 patients (63%) with Ankylosing spondylitis, 33 (21%) had Reactive arthritis, 19 (12%) had Psoriatic arthritis, 6 (4%) had Undifferentiated Spondyloarthritis, and inflammatory bowel disease was diagnosed in 0% in HLA-B27 positive Spondyloarthritis patients. The frequency of HLA-B27 among the Spondyloarthritis (SpA) patients in our study was found to be 54% (156), more common clinical manifestation in men belonging to the age group of 16-25 years positive patients. Ankylosing spondylitis (AS) was found to be the most common sub-groups observed among the SpA patients.

Keywords

Ankylosing spondylitis, HLA-B27, Psoriatic arthritis, Reactive arthritis, RT-PCR Spondyloarthritis

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