ISSN: 0973-7510

E-ISSN: 2581-690X

Mini Review | Open Access
Usha Adiga1, Sachidananda Adiga2, Varashree Bolar Suryakanth3 and Desy Thayyil Menambath1
1Department of Biochemistry, KS Hegde Medical Academy, Nitte (Deemed to be University), Mangalore – 575 018, Karnataka, India.
2Department of Pharmacology, KS Hegde Medical Academy, Nitte (Deemed to be University), Mangalore – 575 018, Karnataka, India.
3Department of Biochemistry, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal – 576 104, Karnataka, India.
J Pure Appl Microbiol. 2022;16(1):18-25 | Article Number: 7140
https://doi.org/10.22207/JPAM.16.1.28 | © The Author(s). 2022
Received: 27/06/2021 | Accepted: 28/09/2021 | Published online: 15/02/2022
Issue online: March 2022
Abstract

Objectives of this review is to evaluate the role of cytochrome P450 gene polymorphisms in COVID-19 infected patients with pre-existing  OA on corticosteroids. The purpose of this review is to analyze whether polymorphisms of Cytochrome p450 isoforms (CYP2C9 and CYP3A4) affect the dosage of steroids in OA patients in COVID-19 infected patients. This review may provide more therapeutic options; suggest a few guidelines which may be useful in managing COVID-19 patients with pre-existing osteoarthritis. The important role of corticosteroids in treating patients infected with COVID-19 with preexisting osteoarthritis, its influence on incidence of mortality or morbidity may be highlighted. The influence of CYP enzymes and their polymorphisms suggest safety of treatments as well as the possible need for the dosage adjustment or their discontinuation.

Keywords

COVID-19, Osteoarthritis, Corticosteroids, Cytochrome P450, Polymorphism

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