ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access
Sapna Chauhan1 , Surender2 and Tony J Rappai3
1Department of Microbiology, Muzaffarnagar Medical College, Muzaffarnagar – 251 001, Uttar Pradesh, India.
2Department of Anaesthesia, Muzaffarnagar Medical College, Muzafffarnagar – 251 001, Uttar Pradesh, India.
3Department of Neurosurgery, Command Hospital, Lucknow 226002, India.
J Pure Appl Microbiol. 2021;15(4):2059-2064 | Article Number: 6951
https://doi.org/10.22207/JPAM.15.4.28 | © The Author(s). 2021
Received: 26/03/2021 | Accepted: 01/09/2021 | Published: 29/09/2021
Abstract

Staphylococcus aureus is one of the common causes of Healthcare-associated infection. Staphylococcus colonizes the anterior nares of the nose and tends to disseminate and secondarily colonize several other body sites including the skin and the gut. Colonized hospital personnel may be an important factor in dissemination. Staphylococcus aureus to patients and vice-versa. Mupirocin is an excellent topical anti-staphylococcal antimicrobial agent used for eradicating nasal carriage. Resistance to Mupirocin is a threat for future use of this drug in eliminating nasal carriage of Staphylococcus aureus. Thus, this study was conducted to determine the rate of Mupirocin resistance among Staphylococcus aureus isolated from nasal swabs of Health care workers (HCWs ) of Operation Theatres (OTs) and Intensive Care Units (ICUs). A single nasal swab was collected from both the anterior nares of participating health care workers of ICU and OT once at the end of their shift. Antibiotic susceptibility testing of Staphylococcus aureus to various antibiotics was done by Kirby-Bauer disk diffusion method using CLSI guidelines. High and low-level Mupirocin resistance was determined. Among 282 nasal swabs collected, Staphylococcus aureus was isolated in 62 samples. Of Staphylococcus aureus 19 came out to be Methicillin-resistant (MRSA) and the remaining 43 Methicillin sensitive (MSSA). Mupirocin resistance was seen in 3 MRSA strains and 1 MSSA strain. Thus, overall 4/62 (6.5%) strains were MupR strains. Mupirocin is the most effective antibiotic used against colonization of Staphylococcus aureus in anterior nares. Resistance to this antibiotic is thus an alarm as well as a matter of great concern. Necessary steps, policies and guidelines need to be framed to stop the spread of this resistance.

Keywords

Mupirocin, Staphylococcus aureus, MRSA, MSSA, nasal swabs

Article Metrics

Article View: 581

Share This Article

© The Author(s) 2021. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.