ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access
Chainika Khatana1, Ashwani Kumar2 , Mashael W. Alruways3, Nazam Khan3, Naveen Thakur4, Dinesh Kumar1 and Amita Kumari5
1Faculty of Applied Sciences and Biotechnology, Shoolini University, Solan – 173 212, Himachal Pradesh, India.
2Patanjali Herbal Research Department, Patanjali Research Institute, Haridwar – 249 405, Uttarakhand, India.
3Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Shaqra University, Shaqra, Saudi Arabia.
4Department of Physics, Career Point University, Hamirpur – 176 045, Himachal Pradesh, India.
5School of Biological and Environmental Sciences, Shoolini University, Solan – 173 212, Himachal Pradesh, India.
J Pure Appl Microbiol. 2021;15(4):1907-1914 | Article Number: 7102 | © The Author(s). 2021
Received: 13/06/2021 | Accepted: 03/09/2021 | Published: 28/09/2021

Microbial infections and antibiotic resistance are some of the prime factors that are ascribed to endanger human health. Several reports have highlighted that drug-resistant pathogens assist in the etiology of various chronic diseases and lead to fatality. The present study deciphered the role of zinc oxide nanoparticles (ZnO NPs) as therapeutics against selected bacterial strains. The plant-based technique was followed to synthesize ZnO NPs. The synthesis was confirmed with different techniques viz. X-ray diffraction, transmission electron microscope (interplanar spacing at 0.126 nm), scanning electron microscope (flower-like structure), and Fourier transform infrared spectroscopy. The antibacterial analysis revealed that ZnO NPs inhibited the growth of all tested strains (Escherichia coli, Staphylococcus aureus, Salmonella typhi, Bacillus subtilis, and Klebsiella pneumoniae) to a greater extent (MIC ranged between 0.013±0.004-0.0625±0 mg/mL) as compared with ZnO compound (Bulk material). In the present study, ZnO NPs were produced in a cost-effective and environmentally sustainable way using a green process and can be used as a remedy for drug-resistant pathogens.


Aloe vera, Zinc oxide nanoparticles, Green synthesis, Characterization, Microbial pathogens

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© The Author(s) 2021. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.