ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access
Anuj Nishanth Lipton1 , Aifa Fathima2 and S.G.P. Vincent2
1Curtin Malaysia Research Institute, Curtin University, CDT 250, 98009 Miri, Sarawak Malaysia.
2Centre for Marine Science & Technology, Manonmaniam Sundaranar University, Rajakkamangalam– 629 502, Tamil Nadu, India.
J Pure Appl Microbiol. 2021;15(3):1455-1471 | Article Number: 7048
https://doi.org/10.22207/JPAM.15.3.39 | © The Author(s). 2021
Received: 19/05/2021 | Accepted: 24/07/2021 | Published: 05/08/2021
Abstract

An opaque, white chitosan/ Hydroxyapatite nanocomposite was prepared by a simple blend method. Morphology, pore size and dispersion of nano-hydroxyapatite in chitosan matrix were visualized using SEM images. The FTIR and SEM with EDX analysis confirmed the bony apatite layer was formed on the outside of the composite. Porosity measurements and water uptake studies of the nanocomposite were evaluated which revealed the maximum porosity of 80% to 92% in the chitosan: hydroxyapatite nanocomposite at the ratio of 20:80. The results also showed that water absorption ability was inversely proportional to the hydroxyapatite present in the nanocomposite. The porosity of prepared nanocomposite was corresponding to the cancellous bone porosity of 50% to 90% suggesting possible applications in bone transplantation. The nanocomposite exhibited antibacterial activity towards the tested Gram-negative and Gram-positive species of bacteria and reduced the bacterial adhesion in biofilm formation.

Keywords

Chitosan, Hydroxyapatite, Nanocomposite, Bone implant, Antibiofilm properties

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