ISSN: 0973-7510

E-ISSN: 2581-690X

Review Article | Open Access
Afzal Hussain and Chandan Kumar Verma
Department of Bioinformatics, Maulana Azad National Institute of Technology, Bhopal – 462 003, Madhya Pradesh, India.
J Pure Appl Microbiol. 2021;15(2):556-579 | Article Number: 6866
https://doi.org/10.22207/JPAM.15.2.49 | © The Author(s). 2021
Received: 20/01/2021 | Accepted: 25/05/2021 | Published: 01/06/2021
Abstract

Candida albicans is a yeast that is an opportunistic fungal pathogen and also identified as ubiquitous polymorphic species that is mainly linked with major fungal infections in humans, particularly in the immunocompromised patients including transplant recipients, chemotherapy patients, HIV-infected patients as well as in low-birth-weight infants. Systemic Candida infections have a high mortality rate of around 29 to 76%. For reducing its infection, limited drugs are existing such as caspofungin, fluconazole, terbinafine, and amphotericin B, etc. which contain unlikable side effects and also toxic. This review intends to utilize advanced bioinformatics technologies such as Molecular docking, Scaffold hopping, Virtual screening, Pharmacophore modeling, Molecular dynamics (MD) simulation for the development of potentially new drug candidates with a drug-repurpose approach against Candida albicans within a limited time frame and also cost reductive.

Keywords

Benzofurans, Benzothiazoles, Biofilm, Inhibitors, Myristoylation, Simulation

Article Metrics

Article View: 49

Share This Article

© The Author(s) 2021. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.