ISSN: 0973-7510

E-ISSN: 2581-690X

Short Communication | Open Access
Rutuja Ankulkar
Praj Matrix R & D Center, Division of Praj Industries Ltd, Pune – 412 115, Maharashtra, India.
J Pure Appl Microbiol. 2021;15(2):594-597 | Article Number: 7021
https://doi.org/10.22207/JPAM.15.2.46 | © The Author(s). 2021
Received: 07/05/2021 | Accepted: 27/05/2021 | Published: 01/06/2021
Abstract

Envelope protein of human coronavirus play significant role in an evolution and mutation of the virus life cycle. In the present research, the author evaluated amino acid sequences, its abundance and GC content of the genes that corresponds to envelope proteins’ of the human coronaviruses, identified from year 2003-2019. It includes SARS-CoV (2003), HCoV-NL-63 (2003), HCoV-HKU-1 (2004), MERS-CoV (2013), and SARS-CoV-2 (2019). The present research findings illustrated a point mutation in D2 location of  SARS-CoV-2 (2019), representing Arginine in the place of Glutamic acid (SARS-CoV, 2003) where glycine was found deleted. SARS-CoV-2 (2019) coronavirus revealed increased abundance of Glutamic acid (100%), Asparagine (67%), Serine (300%) and Valine (85.7%) in comparison with HCoV-NL-63 (2003). We observed lower GC content in the SARS-CoV-2 (2019) among SARS-CoV (2003) and MERS-CoV (2013). The present findings have evolutionary significance and indicate SARS-CoV-2 (2019) adaptation in human.

Keywords

Envelope Protein, Coronaviruses, SARS-CoV-2 (2019), Genetic evolution, GC content, Amino acids, Adaptation

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