ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access
Endah Setyaningrum1, Achmad Arifiyanto1 , Nismah Nukmal1,Titik Nur Aeny2, Meishy Handerlin Putri1 and Ulin Ni’mah Setiawati1
1Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Lampung, Indonesia.
2Department of Plant Protection, Faculty of Agriculture, Universitas Lampung. Jl. Prof. Soemantri Brojonegoro No 1, Gedong Meneng, Rajabasa, Bandarlampung 35144, Lampung, Indonesia.
J Pure Appl Microbiol. 2021;15(2):891-896 | Article Number: 6967
https://doi.org/10.22207/JPAM.15.2.45 | © The Author(s). 2021
Received: 04/04/2021 | Accepted: 26/05/2021 | Published: 01/06/2021
Abstract

Increasing natural ingredient awareness and utilization has created an increased demand for sources of natural medicinal ingredients, including sources of compound used to treat malaria. Streptomyces is a genus of prokaryote well recognized for its production of antibiotics and other pharmaceutically useful compound. This study aimed to assess the ability of unpurified fermentation metabolites to inhibit Plasmodium parasites. A strain of bacteria identified as Streptomyces hygroscopicus subsp. hygroscopicus strain i18 were isolated from pineapple fields in Lampung province, and was cultured and fermented on liquid synthetic Gause medium for 10 days. The supernatant was separated from the cells and extracted with ethyl acetate-methanol (1:1). Plasmodium falciparum 3D7 was used for antiplasmodial testing. Metabolites were tested qualitatively using a phytochemical approach. Saponins and triterpenoids were found to be present in the extract. Parasite inhibition as measured using probit analysis and yielded an IC50 value of 11.07 g.m/L. These findings suggest further examinations of this extract (e.g. assessment of off-target effects) are warranted.

Keywords

Antiparasitic, Actinomycetes, Antimalarial, Parasite, Microbes

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© The Author(s) 2021. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.