ISSN: 0973-7510

E-ISSN: 2581-690X

Mini-Review | Open Access
Ghadeer Turki Aloutaibi1, Abdulrahman L. Al-Malki1,2,3 , Maha J. Balgoon1, Saud A. Bahaidarah4 and Said Salama Moselhy5
1Department of Biochemistry, Faculty of Science, King Abdulaziz University, (KAU), Jeddah, Saudi Arabia.
2Bioactive Natural Products Research Group, KAU. Jeddah, Saudi Arabia.
3Experimental Biochemistry Unit, King Fahd Medical Research Center, KAU, Jeddah, Saudi Arabia.
4Department of Pediatric , Faculty of Medicine,  King Abdulaziz University, (KAU), Jeddah, Saudi Arabia.
5Department of Biochemistry, Faculty of Science, Ain Shams University, Cairo, Egypt.
J Pure Appl Microbiol. 2021; 15(2):580-586 | Article Number: 6862 | © The Author(s). 2021
Received: 18/01/2021 | Accepted: 10/05/2021 | Published: 01/06/2021

Acute rheumatic fever (ARF) triggered by Group A streptococcus bacterium due to post-infectious and non-supportive pharyngeal infection. Depending on certain conditions, such as genetic predisposition to the disease, the prevalence of various cases of rheumatism and socioeconomic status in different regions, ARF can have different clinical manifestations. The disease typically manifested by one or more acute episodes, whereas 30-50% of all repeated ARF status can result in chronic rheumatic heart disease (RHD) with gradual and irreversible heart valve damage and also have been found to be correlated with a raised risk of myocardial infarction (MI), cardiovascular disease (CVD) and dyslipidemia. The RHD is the only long-term consequence of ARF and the most serious. The development to chronic RHD is determined by many factors, most notably the frequent episodes of rheumatic fever (RF). The RHD is known socially and economically as being the most frequent heart disease in vulnerable populations. H. pylori infection has been proposed to be involved RHD greater than that of the normal healthy people. H. pylori can be considered as one of the probable risk factor for RHD.It was concluded that patients with H. Pylori should be advised to follow up in cardiology clinics to avoid any complications.


H. Pylori, Streptococcal A, Rheumatic heart disease

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