ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access
Hani A. Alhadrami1,2 and Raniyah A.M Shoudri1,3
1Faculty of Applied Medical Sciences, Department of Medical Laboratory Technology,
King Abdulaziz University, P. O. Box 80402 Jeddah 21589, Saudi Arabia.
2Molecular Diagnostic Lab, King Abdulaziz University Hospital, King Abdulaziz University, P.O. BOX 80402 Jeddah 21589, Saudi Arabia.
3King Abdul-Aziz Hospital, Ministry of Health, P. O. Box 17040 Jeddah 21484, Saudi Arabia.
J Pure Appl Microbiol. 2021;15(1):437-451 | Article Number: 6794 | © The Author(s). 2021
Received: 01/12/2020 | Accepted: 22/02/2021 | Published: 27/02/2021

Wound infections is one of the major problems worldwide. Millions of people around the world require several medical treatments for wound infections. The extensive use of antibiotics to treat wound infection leads to emerging new microbial strains that are resistant to many antibiotics. There is a growing concern on the emergence and re-emergence of drug-resistant pathogens such as multi-resistant bacterial strains. Hence, the development of new antimicrobial compounds or the modification of those that already exist to improve antibacterial activity is a high research priority. Metallic nanoparticles (NPs) are considered as new alternative treatment for wound infection with superior antibacterial activity. In this study, new formulation of titanium oxide (TiO2) NPs with different sizes were synthesized and characterized. Genotoxicity, mutagenicity and antibacterial activities of TiO2 NPs against the causative agents of wound infection were investigated. Antibacterial activity of TiO2 NPs was conducted against three ATCC® bacterial strains: methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli and Pseudomonas aeruginosa. The results clearly illustrate a superior antibacterial activity of all newly formulated TiO2 NPs against the most causative agents of wound infection. Most of our TiO2 NPs showed non-genotoxic and non-mutagenic results at the maximum concentrations. Findings of this study will enhance the future of the therapeutic strategies against the resistant pathogenic strains that cause wound infections.


TiO2 nanoparticles, antibacterial activity, multi-drug-resistance pathogens, MRSA, E. coli., P. aeruginosa, genotoxicity

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© The Author(s) 2021. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.