Gram Negative Extended Spectrum Beta-Lactamase Producing Bacteria Prevalence in Jouf Region Tertiary Care Hospital, Saudi Arabia

ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access

Javid Iqbal Rather¹, Zahoor Mohi ud din², Farkhanda N. Syed²,
Mir Haris², Mudasar Nabi³, Ambreena Farooq³, Bilal Ahmad Tantry⁴ , Abdul Hafeez Muhammed⁴ and Shaik Rahiman⁵

¹Department of Physiology, GMC Srinagar, Kashmir, Jammu and Kashmir, India.

²Department of Microbiology, GMC Srinagar, Kashmir, Jammu and Kashmir, India.

³Department of Clinical Biochemistry, University of Kashmir, Srinagar, Kashmir, Jammu and Kashmir, India.

⁴Department of Microbiology, Jouf University, College of Medicine, Saudi Arabia.

⁵Department of Biochemistry, Jouf University, College of Medicine, Saudi Arabia.

J Pure Appl Microbiol. 2021;15(1):421-427 | Article Number: 6841

https://doi.org/10.22207/JPAM.15.1.39 | © The Author(s). 2021

Received: 06/01/2021 | Accepted: 16/02/2021 | Published: 27/02/2021

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Abstract

Extended Spectrum beta lactamase producing pathogens are reported in many clinical samples and pose an emerging threat health. To find the prevalence of ESBL producing Enterobactriacea pathogens isolated from inpatients (Medical and Surgical Wards; Hospital stay > 72 h) admitted to Prince, Mutib, Hospital Sakaka, Jouf. A total of 1043 Enterobactriacea were isolated during April 2015 to October 2016 study period. Vitek -2 compact (biomeriux Leon, France) was used for identification and antimicrobial sensitivity (AST) test. A Total of 115/1043 (11.02%) ESBL producing pathogens were isolated from urine 15.07% (n=242), sputum 13.6 % (n=220), wound 10.8% (n=287) and blood 5.4 % (n=294). Klebsiella pneumonia is most dominant followed by E coli and Proteus miribilis. Cephamycins and carbapenems were found most effective (100% sensitivity) against the pathogens isolated. The aminoglycosides, beta lactams and Fluroquinolnes class of antibiotics, microorganisms have gained the resistance of 20%, 22.7%, 40-70% respectively. The infection control measures should be taken seriously and making of effective use of antibiotics is need of hour.

Keywords

ESBL, Gram negative bacteria, Antimicrobial sensitivity test, Antibiotics

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