ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access
Ramadan Yahia1 , Shereen M. Mohammed2, Manal M. Hassanien3,Shabaan H. Ahmed2 and Helal F. Hetta2,4
1Department of Microbiology and Immunology, Faculty of Pharmacy, Deraya University, Minia, Egypt.
2Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Egypt.
3Department of Rheumatology and Rehabilitation, Faculty of Medicine, Assiut University, Assiut, Egypt.
4Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
J Pure Appl Microbiol. 2020;14(4):2453-2465 | Article Number: 6657
https://doi.org/10.22207/JPAM.14.4.23 | © The Author(s). 2020
Received: 18/09/2020 | Accepted: 15/12/2020 | Published: 26/12/2020
Abstract

Rheumatoid arthritis (RA) is a systemic inflammatory disease with chronic nature of joints related to autoimmunity. Vitamin D was found to modulate cell growth, function of immune cells and anti-inflammatory action. The aims of that study were to investigate serum level of vitamin D and some cytokines and to identify the correlation between vitamin D and these cytokines in RA. Totally 40 RA patients without vitamin D supplement were involved in this study. Serum level of vitamin D, interleukin-6 (IL-6), IL-10, IL-35, C-reactive protein (CRP) and tumor necrosis factor α (TNF-α), all of them were measure in all patients by enzyme-linked immunosorbent assay (ELISA). Patients were classified according to Vitamin D levels into two groups; RA patients with Vit. D deficiency (n=25) and RA patients with Vit. D sufficiency (n=15). IL-6 was lower significantly (P = 0.03) in RA patients with Vit. D sufficiency than RA patients with Vit. D deficiency. IL-10 and IL-35 were higher significantly (P = 0.0234, P = 0.0356 respectively) in RA patients with Vit. D sufficiency than RA patients with Vit. D deficiency. Vit. D was significantly positively correlated with both IL-10 (r = 0.4516, P = 0.0034) and IL-35 (r = 0.3424, P = 0.0329) and negatively correlated with IL-6 (r = -0.3188, P = 0.0479). Sufficient serum level of Vit. D is correlated with higher level of anti-inflammatory cytokines (IL-10 and IL-35) and lower level of IL-6. This support the immunomodulatory effect of Vit. D in RA.

Keywords

Vitamin D, Rheumatoid Arthritis, pro-inflammatory, anti-inflammatory, cytokines

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