ISSN: 0973-7510

E-ISSN: 2581-690X

Review Article | Open Access
Hesham A. Malak1,2, Hussein H. Abulreesh1,2 , Sameer R. Organji1,2,Khaled Elbanna1,2,3, Mohammed R. Shaaban1.2,4, Samreen5, Iqbal Ahmad5,Ashwag Shami6, Wafa A. Alshehri7, Ashjan Khalel8, Hiyam H. Abureesh9, Fatimah H. Asiri9, Mohammad S. Aldosari9 and Meshal H.K. Almalki1,2
1Department of Biology, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia.
2Research Laboratories Unit, Faculty of Applied Science, Umm Al-Qura Univeristy, Makkah, Saudi Arabia.
3Department of Agricultural Microbiology, Faculty of Agriculture, Fayoum University, Fayoum, Egypt.
4Department of Chemistry, Faculty of Science, Cairo University, Cairo, Egypt.
5Department of Agricultural Microbiology, Faculty of Agricultural Sciences, Aligarh Muslim University, Aligarh – 202 002, India.
6Biology Department, College of Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
7Department of Biology, College of Science, University of Jeddah, Jeddah, Saudi Arabia.
8Department of Biology, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
9King Abdulaziz Hospital, Makkah, Saudi Arabia.
J Pure Appl Microbiol. 2020;14(4):2219-2234 | Article Number: 6792 | © The Author(s). 2020
Received: 30/11/2020 | Accepted: 15/12/2020 | Published: 24/12/2020

Staphylococcus aureus is a major human pathogen that may cause a wide range of infections and is a frequent cause of soft tissue and bloodstream infections. It is a successful pathogen due to its collective virulence factors and its ability to evade the host immune systems. The review aims to highlight how S. aureus destroys and damage the host cells and explains how immune cells can respond to this pathogen. This review may also provide new insights that may be useful for developing new strategy for combating MRSA and its emerging clones such as community-associated methicillin-resistant S. aureus (CA-MRSA).


Staphylococcus aureus, pathogenesis, immune system, virulence, immune evasion

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© The Author(s) 2020. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.