ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access
Shalini Upadhyay , Anita Chakravarti, Tanisha Bharara and Sushmita Yadav
Department of Microbiology, SGT University, Budhera, Gurugram – 122505, Haryana, India.
J Pure Appl Microbiol. 2020;14(3):2039-2045 | Article Number: 6408
https://doi.org/10.22207/JPAM.14.3.44 | © The Author(s). 2020
Received: 11/05/2020 | Accepted: 25/08/2020 | Published: 08/09/2020
Abstract

The menace of multidrug resistance among bacterial infections is an issue of global public health. Treatment of these superbugs with first line antibiotics is associated with significant treatment failure leading to increased mortality and morbidity. Carbapenems and polymyxins are the saviour antibiotics in case of such infections. But the problem is compounded when these antimicrobials also fail. The addition of beta-lactamase inhibitor like sulbactam and disodium ethylenediaminetetraacetic acid broaden the in vitro antibacterial action of ceftriaxone. This novel combination has been found to be effective in most of the drug resistant bacterial strains.

Keywords

Antibiotic adjuvant, Antibiotic resistance breakers, Carbapenem resistance, Multidrug resistance

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