ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access
Lakshmi Kakhandki , Aparna Y Takpere, Smitha Bagali, Sanjay Wavare, Rashmi Karigoudar and Praveen R Shahapur
Department Of Microbiology, BLDE(DU) Shri. B.M. Patil Medical College, Hospital & Research Centre, Vijayapur – 586 103, Karnataka, India.
J Pure Appl Microbiol. 2020;14(2):1353-1358 | Article Number: 6157
https://doi.org/10.22207/JPAM.14.2.32 | © The Author(s). 2020
Received: 11/03/2020 | Accepted: 16/05/2020 | Published: 12/06/2020
Abstract

The antibiogram gives the periodic summary of antimicrobial susceptibilities of local bacterial isolates submitted to the hospitals microbiology laboratory. Antibiogram can be of great use in assessing the local susceptibility rates and can serve as a tool in designing the empirical antibiotic therapy and also in monitoring the resistance trends over time within in an institution. Pus samples from various clinical conditions like abscess, cellulitis, necrotizing fasciitis, wound infections; diabetic foot ulcers were included in the study. A total of 1124 positive cultures were obtained out of which 736 yielded various Gram negative organisms and 488 were Gram positive organisms. Only Gram negative organisms were considered in the study as gram negative organisms are common etiological agents of skin and soft tissue infections and pose a great challenge to the treating physician as they are known to develop a high antimicrobial resistance. The organisms isolated in our hospital were Pseudomonas aeruginosa (192), Klebsiella pneumonia (173), Escherichia coli (168), Citrobacter species (117), Acinetobacter species (47), and Proteus species (39). In our study which aims at formulating an empirical therapy for Gram negative organisms the drugs with highest sensitivity were Imipenem (51%), Amikacin (43%), Meropenem (38%), Tobramycin (36%), and Ciprofloxacin (34%) Gentamicin (34%), Netimicin (33%), Cotrimoxazole (32%), Piperacillin (28%),Tetracycline (28%), Ceftazidime (28%), Levofloxacin (26%), Ceftriaxone (26%), Colistin (22%), Carbenecillin (21%), Cefoperazone (21%), Cefoperazone +Sulbactum (21%), Azonetrem (21%), Cefipime (20%), Cefuroxime (17%), Cephaxlein (15%), Ampicillin (12%), Amoxyclav (10%). With the knowledge of most commonly isolated organisms causing SSTIs and their antimicrobial susceptibility patterns the clinicians can start the most likely antibiotic and can change accordingly once the sensitivity report is available.

Keywords

Resistance, Antibiogram, Empirical therapy, Pseudomonas aeruginosa, Klebsiella pneumonia

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© The Author(s) 2020. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.