Association of miR-146a Gene Polymorphism with Systemic Lupus Erthymatous Disease

Methak Jasim AL-Jboory

University Musstansiryah, College of Sciences/Iraq.

ABSTRACT

The present study was carried out to detect the association of  microRNA-146a haplotypes polymorphisms with Systemic lupus erythematous (SLE) in Iraqi patients, PCR-SSCP technique used in present study, blood was used to DNA extraction, the results show that there was strong association between microRNA-146a and SLE in one haplotype from two .The present study concluded that there was association between microRNA-146a polymorphisms with SLE, our finding need more investigation to use this polymorphism as early indication of SLE incidence .

Keywords:  Lupus ,MicroRNA, miR-146a, PCR-SSCP technique, Haplotypes,  Polymorphisms.