An Updated Review of Pharmacological, Standardization Methods and Formulation Development of Rutin

Humayun Riaz¹, Syed Atif Raza², Muhammad Shahzad Aslam^*1, Muhammad Syarhabil Ahmad³, Mohammad Ayaz Ahmad⁴ and Povydysh Maria⁵

¹Rashid Latif College of Pharmacy, 35-km- Ferozepur Road, Lahore, Pakistan.
²University College of Pharmacy, University of the Punjab, Lahore, Pakistan.
³School of Bioprocess Engineering, Universiti Malaysia Perlis (UniMAP), Kompleks Pusat Pengajian Jejawi 3 (KPPJ3), Kawasan Perindustrian Jejawi, 02600, Arau, Perlis, Malaysia.
⁴Department of Physics, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia.
⁵Saint-Petersburg State Chemical-Pharmaceutical Academy, Ministry of Healthcare of the Russian Federation, 14, ul. Prof. Popova, St. Petersburg, 197376 Russia.

ABSTRACT

Rutin is one of important bioflavonoids and biomarker that helps to increase the quality of the herbal product. It has a wide variety of pharmacological applications such as neuroinflammation, anti-hypercholesterolemic, neuroprotective, cardioprotective, wound healing, radioprotective, nephroprotective, hepatoprotective, antiplasmodial, antiarthritic, antiviral, antihypertensive, Antinociceptive, antimicrobial, gastroprotective, antiosteoporotic, anticancer, diuretic and anticonvulsant effect. The current review article helps to identify the current and future prospects of rutin. Most of the previous studies were more focus on their pharmacological activities and to understand their mechanism of action but less focus on its clinical trial, commercial potential and formulation development. This review article documents the pharmacological activities, standardization methods and formulation development over the last six years.

Keywords: Rutin, Standardization, Pharmacology, Formulation development.