Humayun Riaz1, Syed Atif Raza2, Muhammad Shahzad Aslam*1, Muhammad Syarhabil Ahmad3, Mohammad Ayaz Ahmadand Povydysh Maria5

1Rashid Latif College of Pharmacy, 35-km- Ferozepur Road, Lahore, Pakistan.
2University College of Pharmacy, University of the Punjab, Lahore, Pakistan.
3School of Bioprocess Engineering, Universiti Malaysia Perlis (UniMAP), Kompleks Pusat Pengajian Jejawi 3 (KPPJ3), Kawasan Perindustrian Jejawi, 02600, Arau, Perlis, Malaysia.
4Department of Physics, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia.
5Saint-Petersburg State Chemical-Pharmaceutical Academy, Ministry of Healthcare of the Russian Federation, 14, ul. Prof. Popova, St. Petersburg, 197376 Russia.


Rutin is one of important bioflavonoids and biomarker that helps to increase the quality of the herbal product. It has a wide variety of pharmacological applications such as neuroinflammation, anti-hypercholesterolemic, neuroprotective, cardioprotective, wound healing, radioprotective, nephroprotective, hepatoprotective, antiplasmodial, antiarthritic, antiviral, antihypertensive, Antinociceptive, antimicrobial, gastroprotective, antiosteoporotic, anticancer, diuretic and anticonvulsant effect. The current review article helps to identify the current and future prospects of rutin. Most of the previous studies were more focus on their pharmacological activities and to understand their mechanism of action but less focus on its clinical trial, commercial potential and formulation development. This review article documents the pharmacological activities, standardization methods and formulation development over the last six years.

Keywords: Rutin, Standardization, Pharmacology, Formulation development.