G.J. Christian* S. Elansekaran, M. Ramamurthy,V. Srinivasan, P. Shanmugapriya and M. Nijavizhi

National Institute of Siddha, Tambaram Sanatorium, Chennai – 600 047, India.

Abstract

Non healing ulcers constitute apotentially serious medical and as well as surgical illness. Wounds that contain necrotizing and less perfused (low oxygen content) tissue take longer to close and heal without proper clearing of dead or nonviable tissue. The Siddha formulation “OonPoochuThailam”(OPT)is indicated for curingsloughing ulcers, sinuses and fistulae, supposedly by acting as a chemical debriding agent(like topical debriding agent). In this present study it was aimed for screening the antimicrobial activities of the ingredients of OonPoochuThailam and to analyze the elemental constituents of the ingredients [salt of Achyranthesaspera(AA), and salt of Sesamumindicum(SI)plant] by using Inductively Coupled Plasma Mass Spectrometry (ICP-MS).The antimicrobial activity of the ingredients of OPT were studied in theconcentration of 100μg/ml against Escherichia coli, Klebsiellapneumonia, Proteus mirabilis, Staphylococcusaureus, Pseudomonasaeruginosa, Shigellasonnei, Aeromonashydrophila, Salmonella typhimurium,Vibrio cholera, Bacillus cereus and Candida albicans. Antibacterial and antifungal potential of the OPT ingredients were assessed both individually and together in terms of zone of inhibition of bacterial and fungal growths.The test items 1(AA),2(SI) and 4(Mixture of AA, SI & SA) have shown a broad spectrum of anti-microbial activity against bacteria and fungi.

Keywords: OonPoochuThailam; Sinus ; Fistula; Debridement ; Wound.