ISSN: 0973-7510

E-ISSN: 2581-690X

Open Access
Masjedi Mansoor1, Zand Farid2, Sabetian Golnar3, Maghsoudi Behzad4 and Savaie Mohsen5*
1Assistant professor of anesthesiology and critical care medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
2Professor of anesthesiology and critical care medicine, Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3Assistant professor of anesthesiology and critical care medicine, Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
4Associate professor of Anesthesiology and critical care medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
5Anesthesiologist, Subspecialty resident of critical care medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
J Pure Appl Microbiol. 2016;10(4):2655-2662
https://doi.org/10.22207/JPAM.10.4.23 | © The Author(s). 2016
Received: 13/06/2016 | Accepted: 19/09/2016 | Published: 31/12/2016
Abstract

Ventilator associated pneumonia may occur as a complication, in intubated patients under mechanical ventilation. In this study, we investigated the impact of early replacement of conventional endotracheal tube with an endotracheal tube with subglottic suction port on the incidence of ventilator associated events. We designed a randomized clinical trial, and enrolled 60 critical care trauma patients (31 in control group and 29 in intervention group). Conventional endotracheal tube was replaced with an endotracheal tube with subglottic suction port during first 12 hours of arrival in ICU in the intervention group. The incidence of ventilator associated conditions includinge ventilator associated pneumonia was measured, and compared between two groups. The incidence of ventilator associated conditions, infection-related ventilator associated complications, ventilator associated pneumonia according to center of disease control and prevention (CDC) criteria, and ventilator associated pneumonia according to clinical pulmonary infection score (CPIS) in control group versus intervention group were: 12.9% vs. 20.7% (P= 0.419), 3.23% vs. 13.8% (P= 0.419139), 54.8% vs. 44.8% (P= 0.438), and 34.5% vs. 32.3% (P= 0.855), respectively. Ventilator free days, intensive care unit length of stay and hospital costs in control group versus intervention group were: 10.26±10.26 days vs. 15.14±10.34 days (P= 0.062), 19.10±14.89 days vs. 16.70±12.37 days (P= 0.604), and 1057.64±1303.54$ vs. 1189.14±1072.72$ (P= 0.186), respectively. According to our study results, the replacement of conventional endotracheal tube with an endotracheal tube with subglottic suction port, cannot be recommended as routine, because of undetermined its capability to reduce ventilator associated events and hospital costs, and also concerns about some risks such as airway loss and pulmonary aspiration. Further investigations are recommended.

Keywords

Intensive care unit, Trauma, Ventilator associated pneumonia, Endotracheal intubation.

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© The Author(s) 2016. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.