Dyslipidemia contributes to the rate of progression of atherosclerosis and chronic kidney disease. Also chronic kidney disease leads to the development of secondary abnormalities in lipid metabolism that contribute to increased cardiovascular morbidity and mortality. on lipid induced glomerular damage.Present study was conducted to assess cardiac risk among the patient of CKD. The study comprised into two groups 30 morbid and 42 healthy control, all were in age group of 20 to 50 years having nephrotic syndrome with ESRD undergoing haemodialysis attending nephrology clinic, male, female ratio 3:2, blood urea, S. creatinine, lipid profile, apolipoprotein A and B were estimated it was found that patient of NS had significantly decreased level of HDL-Chol, Apo A1, Apo A1/Apo B, HDL-Chol./T.Chol. as compared to control same time significantly increased level of T-Chol., TG, LDL-Chol., VLDL-Chol, APO-B, LDL-Chol/HDL-Chol., Apo B/Apo A1.