Fever is a common complaint encountered in clinical practice. Infection is the commonest cause of fever. Though thrombocytopenia has various causes, infection is one of the important cause. Hence the study is conducted to evaluate fever with thrombocytopenia. A prospective study of 200 cases with fever and thrombocytopenia. Patients were evaluated with respect to history clinical features and laboratory profile. Investigations included were

• Blood culture, Widal test, Malaria: Thick and thin smear, Dengue: IgM ELISA, NS1 antigen IC card , Leptospirosis: IgM ELISA.
• Complete hemogram.

Malaria was the commonest cause with 34(17%) cases, followed by Enteric fever 24(12%), Dengue hemorrhagic fever 26(13%) and Leptospirosis 17(8.5%). Apart from infectious diseases, 6(3%) patients with pyelonephritis, 4(2%) patient with hyperplasic bone marrow. Bleeding manifestations were noted in 16% cases. Majority of cases 89(44.5%) had platelet count ranging from 50000-150000. Only 42(21%) cases had count less than 20000. Mortality accounted to 19(9.5%) of the cases. A total of 101(50.5%)cases were suffering from infectious diseases. A major share 89(44.5%)still remained undiagnosed by the available investigations at our center. Hence there is a need for investigation facilities to cover wider range of microbes in a tertiary care hospital for better management of patients and preventive measures.