ISSN: 0973-7510

E-ISSN: 2581-690X

Shyan-Lung Lin , Hua-Wei Lin and Hsing-Cheng Chang
1Department of Automatic Control Engineering, Feng Chia University, Taiwan.
J Pure Appl Microbiol. 2013;7(Spl. Edn.: April):269-276
© The Author(s). 2013
Received: 03/03/2013 | Accepted: 14/04/2013 | Published: 30/04/2013
Abstract

Cerebral Autoregulation (CA) maintains a steady cerebral blood flow within a normal range regardless the variations of blood pressure and other bio-information. CA is a phenomenon describing automatic cerebral regulation to maintain a steady cerebral blood flow (CBF), or cerebral blood volume (CBV). Studies of CA modeling may involve with cerebral hemodynamics, intracranial hemodynamics, CSF dynamics, and ICP dynamics.In this paper, we employed the electric analog of intracranial dynamics to implement the CA simulator with Matlab platform. The model of the arterial-arteriolar cerebrovascular bed was proposed by Ursino with description of blood dynamics and biomechanics from the viewpoints of both cerebral circulation and intracranial space. With the fulfillment of this CA simulator, we can successfully the dynamics of blood vessels in brain subject to possible variations toward cerebral autoregulation.  We demonstrated the CA relations of wall thickness vs. radius of artery, hydraulic conductance vs. radius of artery, blood volume vs. radius of artery, elastic stress vs. radius of artery, smooth muscle tension vs. radius of artery, middle cerebral artery vs. transmural pressure, and temporal responses of artery radius and cerebral blood flow.

Keywords

Cerebral autoregulation, intracranial dynamics, cerebrovascular bed, simulator

Article Metrics

Article View: 757

Share This Article

© The Author(s) 2013. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.