A Bio-chemical and Microbiological Appraisal on the Stability of the Second-line Anti-Tuberculosis Drug, Cycloserine in Mycobacterium tuberculosis

ISSN: 0973-7510

E-ISSN: 2581-690X

A Bio-chemical and Microbiological Appraisal on the Stability of the Second-line Anti-Tuberculosis Drug, Cycloserine in Mycobacterium tuberculosis

Rishan Singh

University of KwaZulu-Natal, Republic of South Africa.

J Pure Appl Microbiol. 2012;6(1):209-211

Received: 03/11/2011 | Accepted: 08/12/2011 | Published: 31/03/2012

Abstract

Cycloserine (C₃H₆N₂O₂) is a second-line drug that is used to treat tuberculosis. Second-line drugs are usually administered to tuberculosis patients when treatment with first-line TB drugs fail or their effect in combination therapies fail or are adverse. Cycloserine has been associated with a number of adverse effects, mostly because of its instability and high levels of toxicity. This article is germane in that it addresses a way of eliminating the instable nature of this drug by studying this drug microbiologically and bio-chemically.

Keywords

Cycloserine, Broth microdilution method, pH, Electon-rich, Electron-deficient

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