Cytokine levels in Type-2 Diabetes Mellitus (T2DM) Patients with Asymptomatic Bacteriuria (ASB) in Northern Andhra Pradesh

ISSN: 0973-7510

E-ISSN: 2581-690X

Research Article | Open Access

K.V.S.B. Vidya Sagar^1,2 , P. Sarat Jyotsna³, K. Sethumadhavan¹ and Narasinga Rao Bandaru²

¹Department of Microbiology, Aarupadai Veedu Medical College and Hospital, Vinayaka Mission Research Foundation [VMRF-DU], Puducherry, Tamil Nadu, India.

²Department of Microbiology, Gayatri Vidya Parishad Institute of Health Care and Medical Technology, Visakhapatnam, Andhra Pradesh, India.

³Department of Nephrology, Government Medical College, Srikakulam, Andhra Pradesh, India.

Article Number: 9330 | © The Author(s). 2024

J Pure Appl Microbiol. 2024;18(2):1246-1252. https://doi.org/10.22207/JPAM.18.2.45

Received: 28 February 2024 | Accepted: 08 May 2024 | Published online: 31 May 2024

Issue online: June 2024

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Abstract

Diabetes is a systemic inflammatory condition. The modulation of cytokine levels caused by Asymptomatic Bacteriuria (ASB) infection can lead to altered inflammatory status in various tissues and may affect their homeostasis and function. We aim to estimate the cytokine (IL-6, TNF-α and IL-10) levels in serum of diabetic individuals with and without ASB to study their clinical significance. The current study evaluates the role of cytokines in inflammation caused due to ASB in T2DM patients. Increase in IL-6 and TNF-α levels may indicate renal tissue damage caused due to inflammation by ASB. Whereas increased IL-10 levels is a possible indicator of persistent infection with bacteria which may lead to diabetic renal disease.

Keywords

Diabetes Mellitus, Asymptomatic Bacteriuria, Cytokines, Inflammation

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