The Effects on Degradation Treatment of CMC-HLC/EDC-ADH Hydrogels using Collagenase I and Simulated Body Fluid

ISSN: 0973-7510

E-ISSN: 2581-690X

Xian Li¹, Daidi Fan¹ , Jianjun Deng¹, Junfeng Hui¹, Xiaoxuan Ma¹, Chenhui Zhu¹ and Wenjiao Xue²

¹Shaanxi Key Laboratory of Degradable Biomedical Materials, Department of Chemical Engineering, Northwest University, Taibai North Road 229, Xi’an, Shaanxi 710069, China.

²Shaanxi Provincial Institute of Microbiology, No. 76 Xiying Road, Xi’an 710043, China.

J Pure Appl Microbiol. 2013;7(Spl. Edn.: April):475-480

Received: 03/03/2013 | Accepted: 14/04/2013 | Published: 30/04/2013

Abstract

A novel hydrogel for biomedical applications was successfully fabricated by human-like collagen (HLC) and carboxymethylcellulose (CMC) with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and adipic acid dihydrazide (ADH) as cross-linkers. The interior morphologies of these hydrogels were also characterized before and after degradation by collagenase I and simulated body fluid (SBF). The results of in vitro degradability tests of these hydrogels that the CMC-HLC/EDC-ADH hydrogel in SBF indicated that possesses slow degradability than in collagenase I in vitro. Therefore, the results provided the possibility that CMC-HLC/EDC-ADH hydrogels are suitable for biomedical applications such as soft tissue augmentation for their good biocompatibility.

Keywords

Hydrogel, Collagens I and Simulated body fluid

Download PDF

Article Metrics

Article View: 1242

JPAM.7.spl.edn.1.69 (295 downloads)

Share This Article

© The Author(s) 2013. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.