Cholecystectomy, a common surgical procedure to remove the gallbladder, generally has a low complication rate. However, the emergence of MDR pathogens poses significant challenges in the post-operative management of infections. Multidrug-resistant Klebsiella pneumoniae (MDR-KP) is one of the most emerging issues in bacterial resistance. A 57 year-old woman came to the emergency unit at Dr. Soetomo General Academic Hospital with a chief complaint of pain in the upper and lower abdomen for four days. The patient had a history of cholecystectomy surgery in another hospital two weeks before admission. A cito laparotomy was performed. During surgery, turbid peritoneal fluid mixed with pus and abdominal wall fasciitis necroticans were found. From microbiology examination, MDR-KP was detected in pus. The patient was treated with Meropenem 1 g/8 hours and Amikacin 250 mg/8 hours. Unfortunately, the patient died due to sepsis and multi-organ dysfunctions. This case underscores the importance of vigilant post-operative monitoring and the need for effective infection control measures to manage and prevent MDR-KP infections in surgical patients. Enhanced surveillance and antibiotic stewardship are crucial to mitigating the risks associated with MDR organisms in healthcare settings.