CRE colonization can act as a potential source for subsequent infection with high mortality rate. This study was to determine prevalence of faecal carriage of CRE among hospitalized patients and the associated risk factors for acquisition. A prospective cross-sectional study was carried over one year (August 2019-July 2020) on newly admitted indoor patients screened for CRE. Rectal swab/fecal specimen was collected, processed and interpreted as per CLSI standards. Of the 300 patients screened, 331 Enterobacterales were isolated of which 46 CRE strains were detected in 40 patients giving a prevalence 13.3% (40/300). Highest number of CRE were in the age group >60 years while among the CSE-positive patients, highest cases were in the age group 31-40 years. Males (62.5%) had a higher faecal carriage compared to females (37.5%). E. coli and Klebsiella species were predominant in both CRE and CSE groups (63% and 28.3% in CRE; 47.01% and 37.5% in CSE). Among the 46 CRE isolates, 25 (54.3%) were carbapenemase producers, of which 16 (64%) produced metallo-β lactamases. Highest proportion of CRE cases were found among ICU patients (26.82%). Patients harbouring CSE had a mean length of stay (LOS) of 5.2 days while CRE patients had LOS of 15.4 days. On multivariate analysis, risk factors associated with CRE colonization were previous exposure to antibiotics, surgical intervention, and diabetes mellitus. Effective infection control measures, including early detection and isolation of CRE carriers are essential to prevent spread and improve patient outcomes.