Pseudomonas aeruginosa is a prevalent gram-negative pathogenic bacterium ubiquitous in natural environment. Aquatic environment of wastewater serves as reservoirs of this bacteria and their wide resistance phenomenon to a number of antibiotics is frequently increasing. This study was conducted to determine the prevalence of P. aeruginosa in 10 industrial waste water and 10 tannery waste water samples of whole Dhaka and 65% (13/20) water samples were found positive for P. aeruginosa which was confirmed by both biochemical test & BiologTM Microbial Identification System. Kirby Bauer disc diffusion method was applied for antimicrobial susceptibility testing and isolates showed resistance to most of the commercial antibiotics except neomycin, gentamycin, streptomycin, ciprofloxacin and nalidixic acid, hence confirmed the multidrug resistance (MDR) of P. aeruginosa in wastewater which is one of the life-threatening public health issues all over the world causing ineffectiveness of several antibiotics. So, it is recommended to make sure surface water or food samples not to be contaminated by this antibiotic resistant P. aeruginosa that might be transferred to animal and human. In these circumstances, not only the hygiene practice is the first and foremost prerequisite but also management practices with effective wastewater disposal system can also be a part of awareness. Additionally, appropriate and logical use of antibiotics must be applied to reduce the emergence of multidrug pathogens to environment.