0973-7510 Journal of Pure and Applied Microbiology 2581-690X DR. M.N. Khan 10.22207/JPAM.16.1.75 Are Inflammatory Bowel Disease and Colorectal Carcinoma Associated with Helicobacter pylori? A Prospective Study and Meta-analysis Bouriat Kaoutar Cherif Soumia Sellami Souad Dref Maria Krati Khadija Meriem Meftah Elkhir Elantri Said Amine Abdessamad Rais Hanane Laboratory of Biochemistry, Environment, and Agrifood, Faculty of Sciences and Techniques-Mohammedia, University of Hassan II of Casablanca, Morocco. Department of Anatomy-pathology, The Arrazi Hospital CHU Mohammed VI of Marrakech, Morocco. Clinic of Gynecology, Charite -Universitatsmedizin, Berlin, Germany. Department of Gastroenterology, The Arrazi Hospital CHU Mohammed VI of Marrakech, Morocco. 25 02 2022 16 1 717 728 Copyright © 2022 The Author(s) 2022 This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License which permits unrestricted use, sharing, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.https://creativecommons.org/licenses/by/4.0/

Observational studies regarding the correlation between colorectal carcinoma, inflammatory bowel disease and Helicobacter pylori infection are inconsistent. The present study aims to investigate the association between colorectal adenocarcinoma (CRA) and inflammatory bowel disease (IBD) with H. pylori status in 100 patients who have inflammatory bowel disease and colorectal carcinoma was confirmed disease by histological approach. Besides, a meta-analysis was performed of published studies, to evaluate the link between H. pylori infection and an increased risk of CRC and IBD. Among 67 cases with CRA and 33 cases with IBD, 59.7% and 51.5% were H. pylori positive; respectively. In the meta-analysis, thirty-nine articles were included, involving 13 231 cases with CRC and 2477 with IBD. The pooled odds ratio for CRC and IBD was 1.16 (95%CI = 0.73-1.82) and 0.42 (95%CI = 0.32-0.56); respectively. Our meta-analysis indicates that H. pylori is not associated with CRC.

Keywords Colorectal adenocarcinoma colorectal cancer Helicobacter pylori IBD immunohistochemistry meta-analysis