Journal of Pure and Applied MicrobiologyVol. 6 No. 4

Attempt in the Synthesis of 2-[(2,6-disubstitutedthiocarbamidophenyl)Amino] Benzeneacetic Acid and their Antimicrobial Study

D.T. Tayade and N.G. Jadhao

Department of Chemistry, Government Vidharbha Institute of Science and Humanities, VMV Road, Amravati - 444 604, India.

Received on 24 March 2012 and accepted on 06 May 2012

 

ABSTRACT

Heteroacyclic and Heterocyclic nucleus containing drugs showed remarkable and noticeable drug absorption, transmission and drug activity and effects; hence they created their own status in chemical, pharmaceutical, medicinal, agricultural and drug sciences. Thioamido, benzaimido heterocycles showed an assortment of significances, applications and importances in industrial, pharmaceutical, medicinal and drug chemistry. Considering all these facts into consideration it was thought interesting to synthesize Substitutedthiocarbamides, 2-[(2,6-Disubstitutedthiocarbamidophenyl)amino] benzeneacetic acid by interacting 2-[(2,6-dichlorophenyl)amino]benzeneacetic acid,monosodium salt with various thiourea in isopropanol medium .The justification and identification of the structure of these newly synthesized compounds had been established on the basis of chemical characterization, elemental analysis, and through spectral data.

Keywords : Substitutedthiocarbamides, 2[(2,6Disubstitutedthiocarbamidophenyl) amino]benzeneacetic acid and isopropanol.