Journal of Pure and Applied MicrobiologyVol. 4 No. 2

Effect of Herbal Drug on Mast Cell Degranulation activity in Sensitized Rats

Sapan Patel*, Surjeet S. Jat, Prashant K. Meena, Ramanuj Patel, R.C. Saxena and Mahesh Tharani

*School of Studies in Botany ,Vikram University, Ujjain, India. Pest Control and Ayurvedic Drug Research Laboratory S.S.L. Jain College, Vidisha - 464 001, India.

Received on 24 April 2010 and accepted on 18 June 2010



The study showed the effect of Vitex negundo crude extracts on mast cells degranulation activity. It was noticed that 100mg/kg.dose of the herbal drug when given p.o. to the albino rats showed 72% mast cells stabilizing activity which was similar to the standard drug Prednisolone .Only 20% cells were found disrupted the detail phytochemistry of extract showing this activity is under the process.

Keywords : Vitex negundo, Mast cells, degranulation , Anti-inflamatory.