Journal of Pure and Applied MicrobiologyVol. 3 No. 2

Synthesis of a,b-Unsaturated Carbonyl Compound and Effect on Antifungal and Antibacterial Activity

R.C. Jagessar1, S. Gomathinayagam2*, N. Balasubramanian3, V. Shanmugaiah3 and P.T. Manoharan4

1Department of Chemistry, University of Guyana, Faculty of Natural Sciences, Turkeyen Campus, Guyana, South America. 2Department of Microbiology, John's Science Centre, University of Guyana, Guyana, South America. 3Centre for Advanced Studies in Botany, University of Madras, Guindy Campus, Chennai, India. 4Department of Botany, Vivekananda College, Madurai, Tamil Nadu, India.

Received on 05 January 2009 and accepted on 17 April 2009

 

ABSTRACT

Antimicrobial activity of two a,b-unsaturated carbonyl compounds, aldols were investigated using the agar disc diffusion and poison plate methods. Compounds were synthesized via the aldol route in very good yields and were characterized by H NMR, 13C NMR, DEPT-135 and IR spectroscopy. Both compounds were found to be antimicrobial activity. However, their mode of action was more antifungal than antibacterial activity.

Keywords : Antimicrobial Activity, a, b-unsaturated Carbonyl Compounds (Aldols), Agar Well Diffusion