Journal of Pure and Applied MicrobiologyVol. 2 No. 1

Novel Antibacterial Activity of Streptomyces sp. Isolated from Syrian Soil

Mohammed A. Ibrahim*, Rima Albesharat, Khulud Alsouleman and Linda Ismail

National Commission of Biotechnology, Damascus, Syria.

Received on 01 January 2008 and accepted on 12 February 2008



The aim of the study was to screen and identify novel activities of Streptomyces isolates from Syrian soil. Streptomyces isolate designated RW6 showed unusual inhibition pattern against Vibrio fluvialis. On the other hand , Streptomyces RW6 showed no antibacterial activities against Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus and Bacillus subtilis. Possible involvement of plasmid content of Streptomyces isolate RW6 with its novel antibacterial activity against Vibrio fluvialis was studied. Treatment of the isolate with acridine orange resulted in curing of the plasmid as demonstrated by agarose gel electrophoresis, and subsequently the loss of novel pattern of antibacterial activity against Vibrio fluvialis.

Keywords : Streptomyces, Vibrio fluvialis, plasmids, antibiotic resistance, antibacterial activity.