Journal of Pure and Applied MicrobiologyVol. 8 No. Special Edition Nov. 2014

Androgenic Anabolic Activities of Some Substituted Androstan[16,17-c]pyrazoline and Androstan [17,16-c]isoxazole Derivatives

Mohamed M. Abdulla1, Abd El-Galil E. Amr2,3, Mohamed A. Al-Omar2, Azza A. Hussain4* and Mohamed S. Amer4

1Research Unit, Saco Pharm. Co., 6th October City 11632, Egypt. 2Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia. 3Department of Applied Organic Chemistry, National Research Center, Dokki, Cairo, Egypt. 4Department of Chemistry, Faculty of Science, Zagazige University, Zagazige Egypt.

Received on 21 August 2014 and accepted on 30 October 2014

 

ABSTRACT

We herein report the androgenic-anabolic activities of some synthesized substituted androstano[17,16-c]pyrazoline (steroidal structure). Twenty six steroid derivatives 1-11 containing acetyl, ester, methoxy and oxazole moieties attached to a steroid moiety were conveniently synthesized and screened for their androgenic anabolic activities. Synthetic steroid structures linked to a different function groups seem to be a promising approach in the search for novel leads for potent androgenic agents. The detailed synthetic pathways of obtained compounds and androgenic activities were reported.

Keywords : Steroid derivatives, androstanopyrazolines, androstanoisoxazoles, androgenic anabolic activities.