Journal of Pure and Applied MicrobiologyVol. 9 No. 4

Study of Association between Helicobacter pylori Infection and Microalbuminuria in Type-2 Diabetic Patients

MandanaMoghni1, SomayehReiisi2 and HeshmatShahi*3

1Department of Pathology, Shahrekord University of Medical Sciences, Shahrekord, Iran 2Department of Genetics, Faculty of Science, University of Shahrekord, Shahrekord, Iran 3Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Received on 14 September 2015 and accepted on 01 November 2015

 

ABSTRACT

Helicobacter pylori is a prevalent infectious agent in community which could cause gastrointestinal infections. In diabetic patients, microalbuminuria is a significant problem which could threaten their health. Bacterial infections cause renal failure and proteinuria. This study was conducted to investigate the association between H. pylori infection and microalbuminuria in patients with type 2 diabetic. In this case-control study, 86 patients with type 2 diabetic were investigated. The patients were divided into two groups of H. pylori-infected (n: 40) and non H. pylori-infected (n: 46) based on two simultaneous positive tests, rapid urease test (RUT) and ELISA. The patients in the two groups were examined and compared for proteinuria and other blood-urine indices. Of the patients with type 2 diabetes, 40 (46.51%) were H. pylori-infected. The infected type 2 diabetic patients had a significantly higher leakage of protein compared to non-infected diabetic patients (P<0.05). Further, infected patients had a significantly high level of inflammatory indices of C-reactive protein, lipoprotein a, and increase in blood leukocytes (P<0.05). H. pylori infection could increase inflammation in the body and contribute to inducing systemic inflammation and renal disorders. This study also showed that H. pylori infection was significantly associated with microalbuminuria and increase in blood inflammatory markers.

Keywords : Helicobacter pylori, type 2 diabetes mellitus, microalbuminuria.