Journal of Pure and Applied MicrobiologyVol. 9 No. Special Edition May. 2015

Existence of Protection against High Pathogenicity Avian Influenza Virus Subtype H5N1 in a Chinese Population

Xin-Sheng Li1,2, Pei Cui4, Zhong Liu3, Hong-Ying Chen1*, Xiang-Dang Du1, Zong-Mei Huang1 and Bao-An Cui1

1Department of Microbiology and Immunology, College of Husbandry and Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450002, P. R. China. 2Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, Georgia, United States of America. 3Henan Province Red Cross Blood Center, Zhengzhou, 450002, P. R. China. 4Henan Center for Animal Disease Control & Prevention, Animal Husbandry Bureau of Henan Province, Zhengzhou 450008, P. R. China.

Received on 03 August 2014 and accepted on 10 September 2014



A vast number of H5N1 avian influenza outbreaks in poultry have occurred in numerous countries throughout the world, however, so few cases of human infection have been reported, especially in China, suggesting humans may acquire resistance to the H5N1 avian influenza virus. A seroprevalence survey was conducted among humans on high pathogenicity avian influenza (HPAI) virus subtype H5N1. Human serum samples from 915 healthy blood donors, 1,223 pig sera from three pig slaughterhouses and 2,120 chicken eggs from a number of supermarkets in Zhengzhou were collected to test for H5N1 antibodies by Haemagglutination inhibition. Among the human blood donors tested 89% were positive for antibodies against HPAI virus subtype H5N1, with an average titer of 25.8; the positive rate of 2120 chicken egg samples was 100%; whereas all 1223 porcine serum samples were negative. The results indicate that an outbreak of HPAI in humans is unlikely.

Keywords : High pathogenicity avian influenza virus, H5N1 subtype, Serum antibodies, Haemagglutination inhibition.