Journal of Pure and Applied MicrobiologyVol. 8 No. 6

Synergistic Effect of Aloe vera and Curcuma longa Extracts in the Inhibition of Drug-Resistant E. coli

Vanka Kanth Swaroop, Aparna Mukherjee, Astha Sinha, Supriya Donthi and William Jabez Osborne*

SBST, VIT University, Vellore, Tamil Nadu - 632014, India.

Received on 10 September 2014 and accepted on 20 November 2014



The excessive and inappropriate application of antibiotics has led to the emergence of drug resistant bacteria. The present study was focused on isolation of bacterial strains which have gained resistance to cefixime, a third generation drug. The isolate VITSSA4 was isolated from sewage treatment plant and was found to show resistance to cefixime at a concentration of 10,000 mgL-1. Further effort was made to develop an effective drug, by using combination of medicinal plant extract of Aloe vera and Curcuma longa. It was evident that the methanolic extract of Aloe vera and Curcuma longa was effective in inhibiting the growth of the isolate VITSSA4. The phenotypic and genotypic characterization revealed that the isolate VITSSA4 was showing 99.9% similarity to E. coli. Thus antibacterial activity of the drugs can be enhanced by Aloe vera and Curcuma longa extract.

Keywords : Cefixime, Multi drug resistance, Synergism, Aloe vera, Curcuma longa.