Journal of Pure and Applied MicrobiologyVol. 8 No. Special Edition Nov. 2014

Synthesis and Antimicrobial Activity of Some Novel 8-Hydroxy-7-Iodoquinoline-5-Sulfonamide Derivatives

Nagy M. Khalifa1,2*, Ahmad Eweas2,3, Mohamed A. Al-Omar1 and Wael Hozzein4,5

1Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia. 2Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division, National Research Centre, Dokki 12622, Cairo, Egypt. 3Pharmaceutical Chemistry Department, College of Pharmacy, Taif University, Taif, Saudi Arabia. 4Bioproducts Research Chair, College of Science, King Saud University, Riyadh 11451, Saudi Arabia. 5Botany Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.

Received on 06 August 2014 and accepted on 22 October 2014



Herein we report a series of novel 8-hydroxyquinoline-5-sufonamide derivatives, which were synthesized, characterized and tested as antimicrobial agents in vitro. The reaction of the key intermediate 8-hydroxy-7-iodoquinoline-5-sulfonyl chloride with different secondary amines, aromatic amines, glycine and hydrazine hydrate, followed by reaction of hydrazide derivative with various ketonic and mono acid anhydride compounds yielded the desired sufonamide derivatives. All the new compounds were characterized by spectral and elemental analyses. Some of the newly synthesized final compounds were evaluated for their in vitro antibacterial and antifungal activities against pathogenic strains. The preliminary screening results indicated that most of the compounds demonstrated moderate to good antibacterial and antifungal activities, comparable to the standard drugs.

Keywords : 8-Hydroxy-7-iodoquinoline; Hydrazide-hydrazone derivatives; Schiff,s bases; Antimicrobial activities.