Journal of Pure and Applied MicrobiologyVol. 8 No. Special Edition Nov. 2014

Biochemical and Histopathological Damages caused by Antimalarial drug, Chloroquine in Liver and Spleen of Wistar Rat

Muheet Alam Saifi

Department of Zoology, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Kingdom of Saudi Arabia.

Received on 06 August 2014 and accepted on 28 October 2014

 

ABSTRACT

The aim of this study was to investigate the effects of chloroquine on two vital tissues in wistar rat (liver and spleen). Healthy adult male wistar rat weighing between 100 and 150 g were used for this study. The treated group was given 200 mg/kg body weight/day of chloroquine phosphate orally for 25 days. Control animals were kept on distilled water. Microscopic examination of liver and spleen tissues revealed changes in histology. The results of our study showed that prolonged exposure to the antimalarial drug chloroquine phosphate results in adverse damages on tissues.

Keywords : Antimalarial drug, Chloroquine, Liver, Spleen and Wistar rat.