Journal of Pure and Applied MicrobiologyVol. 8 No. Special Edition Nov. 2014

Antimicrobial Evaluation of Some Pyridone and Hydantoin N-glycosides Carrying Pyrene Moiety

Nagy M. Khalifa1,2*, Mohamed A. Al-Omar1, Abd El-Galil E. Amr1,3 and Sherein I. Abd-Elmoez4

1Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh, 11451 Saudi Arabia. 2Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division, National Research Centre, 12622-Dokki, Cairo, Egypt. 3Applied Organic Chemistry Department, National Research Centre, 12622-Dokki Cairo, Egypt. 4Microbiology and Immunology Department, National Research Centre, El-Behoos Street, Dokki,Cairo 12622, Egypt.

Received on 30 August 2014 and accepted on 21 October 2014

 

ABSTRACT

In our previous work, some of imidazole and pyridone carrying pyrene derivatives were synthesized before. The potential antimicrobial effects of the synthesized compounds were screened for qualitative (zone of inhibition) and quantitative antibacterial activity (MIC) by agar diffusion test and microtitration methods, respectively, using a variety of microorganisms (S. Typhimurium and P. aeruginosa ) as Gram –ve bacteria, (S. aureus) as Gram +ve bacteria and (C. albicans and A. flavus) as yeast. Some of them exhibited promising activities and the other compounds exhibited moderate activity when compared to standard reference drug.

Keywords : Imidazole derivatives; Pyridones; glycosides; Antimicrobial activities.