Journal of Pure and Applied MicrobiologyVol. 8 No. Special Edition Nov. 2014

Nuclease Composition with Anti-Rabies Activity

Nailya Khismatullina1, Arkadiy Ivanov1, Ekaterina Martynova2, Alexander Mironov1, Elmira Zainutdinova2, Svetlana Khaiboullina2, Albert Rizvanov2 and Maria Filimonova2*

1Federal Center for Toxicological, Radiation and Biological Safety, 420075, 2-Nauchniyi gorodok, Kazan, Tatarstan, Russia. 2Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008, Kremliovskaya st. 18, Kazan, Tatarstan, Russia.

Received on 02 August 2014 and accepted on 19 September 2014

 

ABSTRACT

A composition demonstrating anti-rabies activity was developed on the basis of isoform Sm1 of Serratia marcescens endonuclease. Besides the enzyme the composition contained Haemodes-N, magnesium sulfate and sodium chloride. Injection of this composition at a mouse’s infection cite, two hours after the mouse has been infected with rabies, showed an increase of the infected animals’ survival by more than 30% in comparison with the animals of control group.

Keywords : Nuclease, Serratia marcescens, Sma nuc, Rabies, Postexposure protection.