Journal of Pure and Applied MicrobiologyVol. 8 No. Special Edition Nov. 2014

Follicle-Stimulating Hormone (FSH) Activities of Some Synthesized Candidates

Mohamed M. Abdulla1*, Abd El-Galil E. Amr2,3, Nagy M. Khalifa3 and Mohamed A. Al-Omar3

1Research Unit, Saco Pharm. Co., 6th October City 11632, Egypt. 2Applied Organic Chemistry Department, National Research Center, Dokki, Cairo, Egypt. 3Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.

Received on 21 August 2014 and accepted on 30 October 2014

 

ABSTRACT

A series of pyridines, pyrimidinone, oxazinones, and their derivatives (1-14) were synthesized and screened as follicle-stimulating hormone (FSH) agents using abietic acid as the starting material. The pharmacological screening showed that many of these compounds have good follicle-stimulating hormone (FSH) activity comparable to Pergonal® as reference drug. The detailed synthetic pathways of obtained compounds and Follicle-stimulating hormone (FSH) activity were reported.

Keywords : Abietic acid, Oxazinone, Pyrimidinone, Follicle-stimulating hormone (FSH) activity.