Journal of Pure and Applied MicrobiologyVol. 8 No. May 2014 Special Edition

Fungemias Following Liver or Kidney Transplantation: A Clinical Analysis of 17 Patients

Xinmin Nie1, Qiquan Wan2*, Qifa Ye2,3 and Jiandang Zhou1

1Department of Clinical Laboratory, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, China. 2Department of Transplant Surgery, the Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, China. 3Department of Transplant Surgery, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei, China.

Received on 12 April 2014 and accepted on 09 May 2014

 

ABSTRACT

The present study is to investigate the clinical manifestations, distribution and characteristics of drug susceptibility of pathogens among liver or kidney transplant recipients with fungemias. Seventeen patients developed 21 episodes of fungemias between January 2003 and December 2013. Retrospective analysis to the pathogens and their drug susceptibility characteristics was carried out. The clinical and laboratory data on patients were obtained by hospital record review. Candida spp. accounted for 90.5% of all pathogens (18/21). The most common fungus was Candida albicans (7/21), followed by candida parapsilosis (6/21). Death occurred in 52.9% (9/17) of patients with fungemias. The fungi were relatively sensitive to amphotericin B, flucytosine, voriconazole and caspofungin. The clinical manifestations of fungemias included high body temperature, onset in the early period after liver transplantation as well as high mortality. The antibiotic resistant rate of pathogens causing fungemias was low among liver or kidney transplantation.

Keywords : Liver transplant; Kidney transplant; Fungemia; Drug resistance.