Journal of Pure and Applied MicrobiologyVol. 3 No. 2

Comparative Study of Efficacy of Fixed Dose Combination of Ceftriaxone Sulbactam and Ceftriaxone Tazobactam

Sanjay Mohan Shrivastava,* Sanjeev Kumar Shukla, Shailesh Kumar and Manu Chaudhary

Venus Medicine Research Centre, Hill Top Industrial Estate, Jharmajri EPIP, Phase I (Extn) Bhatoli Kalan, Baddi - 173 205, India.

Received on 11 February 2009 and accepted on 14 April 2009



In the present study, comparative efficacy of ceftriaxone sulbactam and ceftriaxone tazobactam combinations against Bacillus subtilis (MTCC NO. - 736), Pseudomonas aeruginosa (MTCC NO. - 1688), Escherichia coli (MTCC NO. - 739) and Klebsiella pneumoniae ( MTCC NO. - 109) was observed. Antibiotic Susceptibility Test (AST) and Minimum Inhibitory Concentration (MIC) of ceftriaxone, sulbactam, tazobactam, ceftriaxone sulbactam combination and ceftriaxone tazobactam combination were analyzed. The percentage effectiveness of ceftriaxone sulbactam and ceftriaxone tazobactam varied for each bacterial species. The difference of effectiveness between the two antibiotics ranged between 0.48 % to 20.65 %. The maximum difference in effectiveness was noticed against E. coli (20.65%) and the least was observed against P. aeruginosa (0.48%). The MIC value for ceftriaxone sulbactam combination was found to be less as compared to ceftriaxone, sulbactam, tazobactam and ceftriaxone tazobactam combination. In conclusion, the AST and MIC revealed that ceftriaxone sulbactam combination was more effective and can be an excellent therapeutic alternative of ceftriaxone tazobactam and ceftriaxone alone.

Keywords : Minimum Inhibitory Concentration (MIC), Antibiotic Susceptibility Test (AST), Ceftriaxone