Journal of Pure and Applied MicrobiologyVol. 6 No. Special Edition Oct. 2012

Seroprevalence of Hepatitis B Infection in Blood Donors in Western Uttar Pradesh- An Alarming Trend with 5 year Experience

Kafil Akhtar, Murad Ahmad, S.H. Arif, Ghazala Mehdi and Rana Sherwani

Department of Pathology Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India.

Received on 04 March 2012 and accepted on 10 June 2012

 

ABSTRACT

According to WHO, safe blood is a universal right, which means that blood that will not cause any harm to the recipient and that has been fully screened and is not contaminated by any blood-borne disease such as HIV, hepatitis, malaria, or syphilis. Hepatitis B is one of the most common diseases transmitted by blood and individuals with chronic infection have a high risk of developing liver cirrhosis and hepatocellular carcinoma. The current study looks at the sero-prevalence of Hepatitis B infection amongst healthy blood donors coming to Blood Bank, J N Medical College Hospital, AMU, Aligarh during the period 2006-2010. All blood donations (voluntary or replacement) collected over this period were included. Collected samples were screened for hepatitis B surface antigen (HBsAg; Hepalisa, J. Mitra) and Enzyme linked immunosorbent assay (ELISA), to determine the seropositivity of infection in the donors. Of the 53422 units of blood collected over a 5- year period, 24040 (45%) were from voluntary and 29382 (55%) from replacement donors. Among the donors, 1636(3.1%) were positive for Hepatitis B, of which 1546(94.5%) were males and 90 (5.5%) were female donors. The seroprevalence of HBsAg was relatively high (3.1%) in our study when compared to the reported rates in other parts of country and only 5.5% females were positive for HBsAg as compared to 94.5% of males. Safety of the blood supply is dependent on collecting blood from voluntary donors from low-risk populations, screening donated blood for transmissible infections and avoiding unnecessary transfusions. These activities need to be carried out by a well-coordinated blood transfusion service with quality control being implemented at all levels and efforts should be made to increase the number of voluntary donors and reduce replacement donations to a minimum.

Keywords : Blood donors, Hepatitis B infection, Seroprevalence.