Journal of Pure and Applied MicrobiologyVol. 7 No. 4

Antimicrobial Effectiveness of [Cu(pzdc)(phen)2]? 5.5H2O Complex on Some Microorganisms

Cihan Darcan1*, ?zge Kaygusuz2 and T?lin Korkmaz2

1Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Bilecik Seyh Edebali University, Bilecik-Turkey. 2Department of Molecular Biology and Genetics, Institute of Sciences, Bilecik Seyh Edebali University, Bilecik-Turkey.

Received on 24 March 2013 and accepted on 08 May 2013



This study was conducted to find new chemical substances that are highly effective on selected microorganisms from among eight Cu(II) pyrazine-2,3-dicarboxylate complexes, which have been previously synthesized and characterized. The MIC value of the [Cu(pzdc)(phen)2]?5.5H2O complex (8) was determined to be in the range of 15-40 ?g/ml for all bacteria (except the clinical isolate Pseudomonas aeruginosa). However, the minimum microbiocidal concentrations (MMC) (30-200 ?g/ml) were determined to be much higher than the MIC values. In time?kill assays, all the bacteria were fully finished after 120 minutes at 18 ?g/ml and after 240 minutes at 4.5 ?g/ml from 5.54 log. the initial number of bacteria at 37 0C in the lake water. However, all the bacteria were not fully inhibited even at 18 ?g/ml at 10 0C. The same effect was not seen on Candida albicans in spite of the low MIC value (25 ?g/ml). [Cu(pzdc)(phen)2]?5.5H2O complex has broad-spectrum biostatic activity against microorganisms at the MIC values. The mechanism of action is not yet clear.

Keywords : Antimicrobial activity, Disinfectant, Pyrazine-2,3-dicarboxylate complex.